Chloramphenicol Therapy in Pregnancy

Chloramphenicol therapy of typhoid fever.

In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 ...

Erythroid hypoplasia associated with chloramphenicol therapy.

I. 1’.: .‘\O. 42908-H. ‘l’he patient, a 20 year old \viutd lemimaic, was admitted to the hos1)itill 0,1 jumly 10, 1957, “for the enlargement of the neck amul eyes.” I)iagnosis of Graves’ (li5C i5e was Iiiil(iC imicl a therapeumtic diose of 12.3 inc. of I’s’ vas administered. On Noveiiiber 5, 1957, slw vas readmitted oh the oplitimalmiiology service l)ecause of the developmiient of iiialignamit ...

Blindness during Streptomycin and Chloramphenicol Therapy.

ALTHOUGH the toxic effects of streptomycin on the eighth nerve are well known, it is perhaps not so widely appreciated that loss of vision may complicate the administration both of streptomycin and of chloramphenicol. A patient is described who became partially blind during combined streptomycin and chloramphenicol therapy and in whom streptomycin was at first considered to be the toxic agent. ...

Drug Therapy in Pregnancy

Major birth defects affect 3 to 5% of all live births. Most are of unknown etiology, but 1 to 3% of these are thought to be due to pharmaceutical or environmental agents. A teratogen is any chemical, pharmacologic, environmental, or mechanical agent that can cause deviant or disruptive development of the conceptus. Included in this definition are functional impairment, growth restriction, and c...

Chloramphenicol.